Assay Detail
Binding
CHEMBL3101041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.88 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099704 | — | — | 1 | 9.40 |
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 9.15 |
| CHEMBL3099696 | — | — | 1 | 9.05 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 8.74 |
| CHEMBL3099683 | — | — | 1 | 8.49 |
| CHEMBL3099689 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099704 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3099696 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3099683 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3099689 | — | IC50 | = | 3.8 | nM | 8.42 |