Assay Detail
Binding
CHEMBL3101064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA9 preincubated for 15 mins by stopped-flow CO2 hydration method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.53 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78755 | — | — | 1 | 8.89 |
| CHEMBL3099282 | — | — | 1 | 8.01 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.62 |
| CHEMBL3099281 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78755 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL3099282 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL3099281 | — | Ki | = | 279.0 | nM | 6.55 |