Assay Detail
Binding
CHEMBL3101095
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SB-674042 from human orexin-2 receptor after 60 mins by scintillation counting analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.17 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099899 | — | — | 1 | 10.15 |
| CHEMBL3099898 | — | — | 1 | 9.22 |
| CHEMBL3099893 | — | — | 1 | 9.15 |
| CHEMBL3099894 | — | — | 1 | 9.10 |
| CHEMBL3099897 | — | — | 1 | 8.89 |
| CHEMBL3099886 | — | — | 1 | 8.52 |
| CHEMBL3099892 | — | — | 1 | 8.39 |
| CHEMBL3099889 | — | — | 1 | 8.32 |
| CHEMBL3099895 | — | — | 1 | 8.08 |
| CHEMBL3099884 | — | — | 1 | 7.77 |
| CHEMBL3099891 | — | — | 1 | 7.75 |
| CHEMBL3099888 | — | — | 1 | 7.66 |
| CHEMBL3099890 | — | — | 1 | 7.39 |
| CHEMBL3099887 | — | — | 1 | 7.11 |
| CHEMBL3099896 | — | — | 1 | 6.92 |
| CHEMBL3099885 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099899 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL3099898 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3099893 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3099894 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL3099897 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL3099886 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3099892 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL3099889 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL3099895 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL3099884 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3099891 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3099888 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3099890 | — | Ki | = | 40.5 | nM | 7.39 |
| CHEMBL3099887 | — | Ki | = | 78.5 | nM | 7.11 |
| CHEMBL3099896 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL3099885 | — | Ki | = | 580.0 | nM | 6.24 |