Assay Detail
Binding
CHEMBL3101167
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Inhibition of human CYP19 preincubated for 10 mins followed by protein addition measured after 90 mins by fluorimetric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.93 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099686 | — | — | 1 | 7.30 |
| CHEMBL3099683 | — | — | 1 | 5.96 |
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 5.22 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099686 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3099683 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 6000.0 | nM | 5.22 |