Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3101211

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Porphyromonas gingivalis recombinant gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Porphyromonas gingivalis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.
Vullo D, Del Prete S, Osman SM, De Luca V, Scozzafava A, Alothman Z, Supuran CT, Capasso C.
Bioorg Med Chem Lett (2014) 24 : 275 -279
PubMed 24314394 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 40 6.20 6.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL77517 INDISULAM 2.0 1 6.88
CHEMBL750 ZONISAMIDE 4.0 1 6.80
CHEMBL118 CELECOXIB 4.0 1 6.77
CHEMBL6784 — — 1 6.75
CHEMBL6724 — — 1 6.70
CHEMBL2324869 — — 1 6.66
CHEMBL6919 — — 1 6.65
CHEMBL310671 SACCHARIN 3.0 1 6.56
CHEMBL224292 — — 1 6.49
CHEMBL20 ACETAZOLAMIDE 4.0 1 6.49
CHEMBL19 METHAZOLAMIDE 4.0 1 6.46
CHEMBL435 HYDROCHLOROTHIAZIDE 4.0 1 6.42
CHEMBL26 SULPIRIDE 3.0 1 6.38
CHEMBL328560 SULTHIAME 3.0 1 6.37
CHEMBL265674 — — 1 6.29
CHEMBL414 CARZENIDE 2.0 1 6.25
CHEMBL6753 — — 1 6.22
CHEMBL18 ETHOXZOLAMIDE 4.0 1 6.21
CHEMBL7092 — — 1 6.18
CHEMBL6853 — — 1 6.17
CHEMBL6633 — — 1 6.16
CHEMBL218490 DORZOLAMIDE 4.0 1 6.16
CHEMBL418 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE — 1 6.15
CHEMBL220491 BRINZOLAMIDE 4.0 1 6.14
CHEMBL73962 BENZOLAMIDE — 1 6.13
CHEMBL865 VALDECOXIB 4.0 1 6.12
CHEMBL21 SULFANILAMIDE 4.0 1 6.05
CHEMBL7087 — — 1 6.03
CHEMBL419 MAFENIDE 4.0 1 6.03
CHEMBL574 P-TOLUENESULFONAMIDE 3.0 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL77517 INDISULAM Ki = 131.0 nM 6.88
CHEMBL750 ZONISAMIDE Ki = 157.0 nM 6.80
CHEMBL118 CELECOXIB Ki = 169.0 nM 6.77
CHEMBL6784 — Ki = 178.0 nM 6.75
CHEMBL6724 — Ki = 201.0 nM 6.70
CHEMBL2324869 — Ki = 218.0 nM 6.66
CHEMBL6919 — Ki = 223.0 nM 6.65
CHEMBL310671 SACCHARIN Ki = 273.0 nM 6.56
CHEMBL224292 — Ki = 326.0 nM 6.49
CHEMBL20 ACETAZOLAMIDE Ki = 324.0 nM 6.49
CHEMBL19 METHAZOLAMIDE Ki = 343.0 nM 6.46
CHEMBL435 HYDROCHLOROTHIAZIDE Ki = 380.0 nM 6.42
CHEMBL26 SULPIRIDE Ki = 418.0 nM 6.38
CHEMBL328560 SULTHIAME Ki = 424.0 nM 6.37
CHEMBL265674 — Ki = 510.0 nM 6.29
CHEMBL414 CARZENIDE Ki = 560.0 nM 6.25
CHEMBL6753 — Ki = 595.0 nM 6.22
CHEMBL18 ETHOXZOLAMIDE Ki = 613.0 nM 6.21
CHEMBL7092 — Ki = 662.0 nM 6.18
CHEMBL6853 — Ki = 680.0 nM 6.17
CHEMBL6633 — Ki = 685.0 nM 6.16
CHEMBL218490 DORZOLAMIDE Ki = 685.0 nM 6.16
CHEMBL418 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE Ki = 711.0 nM 6.15
CHEMBL220491 BRINZOLAMIDE Ki = 722.0 nM 6.14
CHEMBL73962 BENZOLAMIDE Ki = 741.0 nM 6.13
CHEMBL865 VALDECOXIB Ki = 755.0 nM 6.12
CHEMBL21 SULFANILAMIDE Ki = 893.0 nM 6.05
CHEMBL7087 — Ki = 945.0 nM 6.03
CHEMBL419 MAFENIDE Ki = 945.0 nM 6.03
CHEMBL574 P-TOLUENESULFONAMIDE Ki = 945.0 nM 6.03
CHEMBL17 DICHLORPHENAMIDE Ki = 1035.0 nM 5.99
CHEMBL266240 — Ki = 1040.0 nM 5.98
CHEMBL268439 — Ki = 1450.0 nM 5.84
CHEMBL7146 — Ki = 3400.0 nM 5.47
CHEMBL2324864 — Ki = 3540.0 nM 5.45
CHEMBL269122 — Ki = 4100.0 nM 5.39
CHEMBL6852 — Ki = 4220.0 nM 5.38
CHEMBL266026 — Ki = 4650.0 nM 5.33
CHEMBL220492 TOPIRAMATE Ki > 100000.0 nM -
CHEMBL2324868 — Ki > 100000.0 nM -