Assay Detail
Binding
CHEMBL3101212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Leishmania donovani chagasi recombinant beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania chagasi |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.23 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 7.30 |
| CHEMBL2324864 | — | — | 1 | 7.30 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.29 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.22 |
| CHEMBL7146 | — | — | 1 | 7.13 |
| CHEMBL266026 | — | — | 1 | 7.06 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.06 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.04 |
| CHEMBL268439 | — | — | 1 | 7.02 |
| CHEMBL269122 | — | — | 1 | 6.87 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.72 |
| CHEMBL6784 | — | — | 1 | 6.64 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.63 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.50 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.47 |
| CHEMBL6919 | — | — | 1 | 6.41 |
| CHEMBL6753 | — | — | 1 | 6.36 |
| CHEMBL265674 | — | — | 1 | 6.23 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.15 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.12 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 6.09 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 6.08 |
| CHEMBL224292 | — | — | 1 | 6.03 |
| CHEMBL266240 | — | — | 1 | 5.32 |
| CHEMBL6852 | — | — | 1 | 5.22 |
| CHEMBL6724 | — | — | 1 | 5.08 |
| CHEMBL2324868 | — | — | 1 | 5.05 |
| CHEMBL2324869 | — | — | 1 | 5.04 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 5.04 |
| CHEMBL7092 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 50.2 | nM | 7.30 |
| CHEMBL2324864 | — | Ki | = | 50.2 | nM | 7.30 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 51.5 | nM | 7.29 |
| CHEMBL414 | CARZENIDE | Ki | = | 59.6 | nM | 7.22 |
| CHEMBL7146 | — | Ki | = | 73.4 | nM | 7.13 |
| CHEMBL266026 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 91.7 | nM | 7.04 |
| CHEMBL268439 | — | Ki | = | 95.1 | nM | 7.02 |
| CHEMBL269122 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL6784 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL77517 | INDISULAM | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL865 | VALDECOXIB | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL6919 | — | Ki | = | 389.0 | nM | 6.41 |
| CHEMBL6753 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL265674 | — | Ki | = | 584.0 | nM | 6.23 |
| CHEMBL118 | CELECOXIB | Ki | = | 705.0 | nM | 6.15 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 764.0 | nM | 6.12 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 806.0 | nM | 6.09 |
| CHEMBL328560 | SULTHIAME | Ki | = | 834.0 | nM | 6.08 |
| CHEMBL224292 | — | Ki | = | 927.0 | nM | 6.03 |
| CHEMBL266240 | — | Ki | = | 4819.0 | nM | 5.32 |
| CHEMBL6852 | — | Ki | = | 5960.0 | nM | 5.22 |
| CHEMBL6724 | — | Ki | = | 8420.0 | nM | 5.08 |
| CHEMBL2324868 | — | Ki | = | 8910.0 | nM | 5.05 |
| CHEMBL2324869 | — | Ki | = | 9135.0 | nM | 5.04 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 9083.0 | nM | 5.04 |
| CHEMBL7092 | — | Ki | = | 9058.0 | nM | 5.04 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 9251.0 | nM | 5.03 |
| CHEMBL6853 | — | Ki | = | 15600.0 | nM | 4.81 |
| CHEMBL310671 | SACCHARIN | Ki | > | 100000.0 | nM | - |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | > | 100000.0 | nM | - |
| CHEMBL419 | MAFENIDE | Ki | > | 100000.0 | nM | - |
| CHEMBL7087 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL6633 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL220492 | TOPIRAMATE | Ki | > | 100000.0 | nM | - |
| CHEMBL750 | ZONISAMIDE | Ki | > | 100000.0 | nM | - |
| CHEMBL26 | SULPIRIDE | Ki | > | 100000.0 | nM | - |