Assay Detail
Binding
CHEMBL3101220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha-induced NF-kappaB transcriptional activation in human HepG2 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 1 hr by luciferase reporter gene assay
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New anti-inflammatory cembranoid diterpenoids from the Vietnamese soft coral Lobophytum crassum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.48 | 6.05 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 6.05 |
| CHEMBL3099358 | — | — | 2 | 5.20 |
| CHEMBL3099355 | — | — | 2 | 5.18 |
| CHEMBL3099357 | — | — | 1 | - |
| CHEMBL3099356 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3099358 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3099355 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL3099355 | — | Inhibition | - | % | - | |
| CHEMBL3099358 | — | Inhibition | - | % | - | |
| CHEMBL3099357 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3099356 | — | IC50 | > | 20000.0 | nM | - |