Assay Detail
Functional
CHEMBL3101423
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Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.12 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260926 | — | — | 1 | 6.96 |
| CHEMBL412101 | — | — | 1 | 5.70 |
| CHEMBL3100035 | — | — | 1 | 5.55 |
| CHEMBL3100034 | — | — | 1 | 5.25 |
| CHEMBL3100028 | — | — | 1 | 5.10 |
| CHEMBL3100026 | — | — | 1 | 4.98 |
| CHEMBL3100027 | — | — | 1 | 4.91 |
| CHEMBL3100038 | — | — | 1 | 4.84 |
| CHEMBL3100037 | — | — | 1 | 4.79 |
| CHEMBL3100030 | — | — | 1 | 4.63 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.53 |
| CHEMBL3100029 | — | — | 1 | 4.23 |
| CHEMBL1271483 | — | — | 1 | - |
| CHEMBL3100036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260926 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL412101 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3100035 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3100034 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3100028 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3100026 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3100027 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3100038 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3100037 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL3100030 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL3100029 | — | IC50 | = | 59400.0 | nM | 4.23 |
| CHEMBL1271483 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3100036 | — | IC50 | > | 100000.0 | nM | - |