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Assay Detail

CHEMBL3101426

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse J774 cells assessed as cell survival after 24 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type J774
Confidence 1 — Organism
Curated By Autocuration

Target

J774 (CHEMBL614123)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells.
Salomatina OV, Markov AV, Logashenko EB, Korchagina DV, Zenkova MA, Salakhutdinov NF, Vlassov VV, Tolstikov GA.
Bioorg Med Chem (2014) 22 : 585 -593
PubMed 24268542 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.89 5.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL260926 1 5.48
CHEMBL3100034 1 5.16
CHEMBL3100038 1 4.87
CHEMBL3100037 1 4.70
CHEMBL3100029 1 4.25
CHEMBL6 INDOMETHACIN 4.0 1 -
CHEMBL3100030 1 -
CHEMBL3100028 1 -
CHEMBL3100027 1 -
CHEMBL3100026 1 -
CHEMBL1271483 1 -
CHEMBL3100036 1 -
CHEMBL3100035 1 -
CHEMBL412101 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL260926 IC50 = 3320.0 nM 5.48
CHEMBL3100034 IC50 = 7000.0 nM 5.16
CHEMBL3100038 IC50 = 13400.0 nM 4.87
CHEMBL3100037 IC50 = 20100.0 nM 4.70
CHEMBL3100029 IC50 = 56100.0 nM 4.25
CHEMBL6 INDOMETHACIN IC50 > 100000.0 nM -
CHEMBL3100030 IC50 > 100000.0 nM -
CHEMBL3100028 IC50 > 100000.0 nM -
CHEMBL3100027 IC50 > 100000.0 nM -
CHEMBL3100026 IC50 > 100000.0 nM -
CHEMBL1271483 IC50 > 100000.0 nM -
CHEMBL3100036 IC50 > 100000.0 nM -
CHEMBL3100035 IC50 > 100000.0 nM -
CHEMBL412101 IC50 > 100000.0 nM -