Assay Detail

CHEMBL3101441

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Binding

Inhibition of NDM-1 (unknown origin)

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Not specified
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Simplified captopril analogues as NDM-1 inhibitors.

Li N, Xu Y, Xia Q, Bai C, Wang T, Wang L, He D, Xie N, Li L, Wang J, Zhou HG, Xu F, Yang C, Zhang Q, Yin Z, Guo Y, Chen Y.
Bioorg Med Chem Lett (2014) 24 : 386 -389
PubMed 24269122 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.76	5.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL434965	D-CAPTOPRIL	—	1	5.10
CHEMBL1560	CAPTOPRIL	4.0	1	4.41

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL434965	D-CAPTOPRIL	IC50	=	7900.0	nM	5.10
CHEMBL1560	CAPTOPRIL	IC50	=	39000.0	nM	4.41