Assay Detail
Binding
CHEMBL3101661
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Inhibition of Staphylococcus aureus FabI-mediated trans-2-octenoyl N-acetylcysteamine reduction assessed as NADPH level by ELISA
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Verrulactone C with an unprecedented dispiro skeleton, a new inhibitor of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.19 | 6.04 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011360 | VERRULACTONE A | — | 1 | 6.04 |
| CHEMBL2011361 | VERRULACTONE B | — | 1 | 5.85 |
| CHEMBL3098272 | — | — | 2 | 4.79 |
| CHEMBL593328 | — | — | 2 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011360 | VERRULACTONE A | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2011361 | VERRULACTONE B | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3098272 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL593328 | — | IC50 | = | 85400.0 | nM | 4.07 |
| CHEMBL593328 | — | Inhibition | - | % | - | |
| CHEMBL3098272 | — | Inhibition | - | % | - |