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Assay Detail

CHEMBL3101951

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at NTR1 (unknown origin) expressed in CHO-K1 cells coexpressing beta-arrestin/N-terminal deletion mutant of beta-galactosidase fusion protein by chemiluminescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neurotensin receptor type 1 (CHEMBL4123)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Imidazole-derived agonists for the neurotensin 1 receptor.
Hershberger PM, Hedrick MP, Peddibhotla S, Mangravita-Novo A, Gosalia P, Li Y, Gray W, Vicchiarelli M, Smith LH, Chung TD, Thomas JB, Caron MG, Pinkerton AB, Barak LS, Roth GP.
Bioorg Med Chem Lett (2014) 24 : 262 -267
PubMed 24332089 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 5.21 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3099773 1 5.21
CHEMBL508044 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3099773 EC50 = 6100.0 nM 5.21
CHEMBL508044 EC50 > 33000.0 nM -