Assay Detail
Binding
CHEMBL3102013
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Inhibition of GST-tagged recombinant human cytomegalovirus DNA polymerase catalytic subunit UL54 expressed in baculovirus infected insect Sf21 cells assessed as incorporation of biotin-tagged dUTP after 30 mins by LANCE TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Cell Type | Sf21 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New inhibitors of cytomegalovirus DNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.49 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099827 | — | — | 1 | 7.66 |
| CHEMBL3099826 | — | — | 1 | 7.52 |
| CHEMBL3099825 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099827 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3099826 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3099825 | — | IC50 | = | 50.0 | nM | 7.30 |