Assay Detail
Binding
CHEMBL3102089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]MIP-1alpha from rat CCR1
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure activity relationships of fused bicyclic and urea derivatives of spirocyclic compounds as potent CCR1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.46 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099943 | — | — | 1 | 7.80 |
| CHEMBL3099945 | — | — | 1 | 7.30 |
| CHEMBL3099944 | — | — | 1 | 7.30 |
| CHEMBL3099946 | — | — | 1 | 7.05 |
| CHEMBL3099947 | — | — | 1 | 7.00 |
| CHEMBL3099941 | — | — | 1 | 6.35 |
| CHEMBL3099951 | — | — | 1 | 5.90 |
| CHEMBL3099948 | — | — | 1 | 5.80 |
| CHEMBL3099950 | — | — | 1 | 5.79 |
| CHEMBL3099942 | — | — | 1 | 5.75 |
| CHEMBL3099960 | — | — | 1 | 5.75 |
| CHEMBL3099949 | — | — | 1 | 5.68 |
| CHEMBL3099959 | — | — | 1 | - |
| CHEMBL3099958 | — | — | 1 | - |
| CHEMBL3099957 | — | — | 1 | - |
| CHEMBL3099956 | — | — | 1 | - |
| CHEMBL3099955 | — | — | 1 | - |
| CHEMBL3099954 | — | — | 1 | - |
| CHEMBL3099953 | — | — | 1 | - |
| CHEMBL3099952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099943 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3099945 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3099944 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3099946 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3099947 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3099941 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL3099951 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL3099948 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL3099950 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL3099942 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3099960 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL3099949 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3099959 | — | IC50 | - | — | - | |
| CHEMBL3099958 | — | IC50 | - | — | - | |
| CHEMBL3099957 | — | IC50 | - | — | - | |
| CHEMBL3099956 | — | IC50 | - | — | - | |
| CHEMBL3099955 | — | IC50 | - | — | - | |
| CHEMBL3099954 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL3099953 | — | IC50 | - | — | - | |
| CHEMBL3099952 | — | IC50 | - | — | - |