Assay Detail
Binding
CHEMBL3102209
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Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells treated 30 mins before LPS challenge measured after 6 hrs by luciferase reporter gene assay
25
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.84 | 6.28 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099444 | — | — | 1 | 6.28 |
| CHEMBL3099443 | — | — | 2 | 6.28 |
| CHEMBL475942 | — | — | 1 | 6.12 |
| CHEMBL3099442 | — | — | 1 | 6.09 |
| CHEMBL3099434 | — | — | 1 | 6.05 |
| CHEMBL3099445 | — | — | 1 | 5.99 |
| CHEMBL3099441 | — | — | 1 | 5.79 |
| CHEMBL3099452 | — | — | 1 | 5.79 |
| CHEMBL3099437 | — | — | 1 | 5.76 |
| CHEMBL403183 | — | — | 1 | 5.76 |
| CHEMBL3099451 | — | — | 1 | 5.75 |
| CHEMBL3099438 | — | — | 1 | 5.67 |
| CHEMBL3099449 | — | — | 1 | 5.52 |
| CHEMBL3099439 | — | — | 1 | 5.43 |
| CHEMBL3099440 | — | — | 1 | 5.38 |
| CHEMBL3099453 | — | — | 1 | - |
| CHEMBL3099454 | — | — | 1 | - |
| CHEMBL3099450 | — | — | 1 | - |
| CHEMBL3099435 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
| CHEMBL3099448 | — | — | 1 | - |
| CHEMBL3099447 | — | — | 1 | - |
| CHEMBL3099446 | — | — | 1 | - |
| CHEMBL3099436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099444 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3099443 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL475942 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3099442 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3099434 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3099445 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3099441 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3099452 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3099437 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL403183 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL3099451 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL3099438 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL3099449 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL3099439 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL3099440 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL3099453 | — | IC50 | - | — | - | |
| CHEMBL3099454 | — | IC50 | - | — | - | |
| CHEMBL3099450 | — | IC50 | - | — | - | |
| CHEMBL3099435 | — | IC50 | - | — | - | |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - | |
| CHEMBL3099448 | — | IC50 | - | — | - | |
| CHEMBL3099447 | — | IC50 | - | — | - | |
| CHEMBL3099446 | — | IC50 | - | — | - | |
| CHEMBL3099436 | — | IC50 | - | — | - | |
| CHEMBL3099443 | — | Inhibition | - | % | - |