Assay Detail
Functional
CHEMBL3102586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.18 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.97 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.73 |
| CHEMBL3098963 | — | — | 1 | 7.46 |
| CHEMBL3098959 | — | — | 1 | 7.37 |
| CHEMBL3098964 | — | — | 1 | 7.35 |
| CHEMBL3098967 | — | — | 1 | 7.29 |
| CHEMBL3098957 | — | — | 1 | 7.29 |
| CHEMBL3098955 | — | — | 1 | 7.28 |
| CHEMBL3098956 | — | — | 1 | 7.28 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.23 |
| CHEMBL3098960 | — | — | 1 | 7.21 |
| CHEMBL3098962 | — | — | 1 | 7.16 |
| CHEMBL3098953 | — | — | 1 | 7.14 |
| CHEMBL3098966 | — | — | 1 | 7.08 |
| CHEMBL3098965 | — | — | 1 | 7.05 |
| CHEMBL3098961 | — | — | 1 | 6.92 |
| CHEMBL3098958 | — | — | 1 | 6.83 |
| CHEMBL3098952 | — | — | 1 | 6.80 |
| CHEMBL3098954 | — | — | 1 | 6.71 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 6.40 |
| CHEMBL3098951 | — | — | 1 | - |
| CHEMBL3098950 | — | — | 1 | - |
| CHEMBL3098949 | — | — | 1 | - |
| CHEMBL3098948 | — | — | 1 | - |
| CHEMBL3098947 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 10.63 | nM | 7.97 |
| CHEMBL170 | QUININE | IC50 | = | 18.67 | nM | 7.73 |
| CHEMBL3098963 | — | IC50 | = | 34.97 | nM | 7.46 |
| CHEMBL3098959 | — | IC50 | = | 42.38 | nM | 7.37 |
| CHEMBL3098964 | — | IC50 | = | 44.78 | nM | 7.35 |
| CHEMBL3098967 | — | IC50 | = | 50.82 | nM | 7.29 |
| CHEMBL3098957 | — | IC50 | = | 51.02 | nM | 7.29 |
| CHEMBL3098955 | — | IC50 | = | 52.09 | nM | 7.28 |
| CHEMBL3098956 | — | IC50 | = | 53.11 | nM | 7.28 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 59.09 | nM | 7.23 |
| CHEMBL3098960 | — | IC50 | = | 61.34 | nM | 7.21 |
| CHEMBL3098962 | — | IC50 | = | 68.63 | nM | 7.16 |
| CHEMBL3098953 | — | IC50 | = | 73.03 | nM | 7.14 |
| CHEMBL3098966 | — | IC50 | = | 82.19 | nM | 7.08 |
| CHEMBL3098965 | — | IC50 | = | 88.7 | nM | 7.05 |
| CHEMBL3098961 | — | IC50 | = | 120.65 | nM | 6.92 |
| CHEMBL3098958 | — | IC50 | = | 149.45 | nM | 6.83 |
| CHEMBL3098952 | — | IC50 | = | 157.25 | nM | 6.80 |
| CHEMBL3098954 | — | IC50 | = | 193.15 | nM | 6.71 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 400.7 | nM | 6.40 |
| CHEMBL3098951 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3098950 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3098949 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3098948 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3098947 | — | IC50 | > | 1000.0 | nM | - |