Assay Detail
Binding
CHEMBL3102685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of RTX-induced 45Ca2+ uptake after 20 mins by liquid scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.24 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595069 | IODORESINIFERATOXIN | — | 1 | 8.23 |
| CHEMBL3099610 | — | — | 1 | 7.03 |
| CHEMBL253392 | — | — | 1 | 6.91 |
| CHEMBL3099611 | — | — | 1 | 6.79 |
| CHEMBL3099609 | — | — | 1 | - |
| CHEMBL3099608 | — | — | 1 | - |
| CHEMBL392584 | — | — | 1 | - |
| CHEMBL17976 | RESINIFERATOXIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595069 | IODORESINIFERATOXIN | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL3099610 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL253392 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL3099611 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL3099609 | — | Ki | - | — | - | |
| CHEMBL3099608 | — | Ki | - | — | - | |
| CHEMBL392584 | — | Ki | - | — | - | |
| CHEMBL17976 | RESINIFERATOXIN | Ki | - | — | - |