Assay Detail
Binding
CHEMBL3106083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.23 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3105692 | — | — | 1 | 7.60 |
| CHEMBL3105671 | — | — | 1 | 7.50 |
| CHEMBL3105681 | — | — | 1 | 7.40 |
| CHEMBL3105815 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3105692 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3105671 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL3105681 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL3105815 | — | Ki | = | 398.11 | nM | 6.40 |