Assay Detail
Binding
CHEMBL3106113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from sigma 2 receptor (unknown origin)
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.60 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 2 | 8.00 |
| CHEMBL3104093 | — | — | 2 | 6.51 |
| CHEMBL3104092 | — | — | 2 | 6.28 |
| CHEMBL3104091 | — | — | 2 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL3104093 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL3104093 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL3104092 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL3104092 | — | Ki | = | 524.81 | nM | 6.28 |
| CHEMBL3104091 | — | Ki | = | 2234.0 | nM | 5.65 |
| CHEMBL3104091 | — | Ki | = | 2238.72 | nM | 5.65 |