Assay Detail
Binding
CHEMBL3106116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin)
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.13 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3544974 | ASENAPINE MALEATE | 4.0 | 2 | 8.24 |
| CHEMBL30 | CIMETIDINE | 4.0 | 2 | 7.16 |
| CHEMBL3104091 | — | — | 2 | 7.09 |
| CHEMBL3104093 | — | — | 2 | 6.03 |
| CHEMBL3104092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3544974 | ASENAPINE MALEATE | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL3544974 | ASENAPINE MALEATE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL30 | CIMETIDINE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL30 | CIMETIDINE | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL3104091 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL3104091 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL3104093 | — | Ki | = | 943.0 | nM | 6.03 |
| CHEMBL3104093 | — | Ki | = | 933.25 | nM | 6.03 |
| CHEMBL3104092 | — | Ki | > | 10000.0 | nM | - |