Assay Detail
Binding
CHEMBL3106122
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Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.97 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 2 | 9.54 |
| CHEMBL3104091 | — | — | 2 | 6.64 |
| CHEMBL3104093 | — | — | 2 | 6.39 |
| CHEMBL3104092 | — | — | 2 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL3104091 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL3104091 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL3104093 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL3104093 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL3104092 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3104092 | — | Ki | = | 1819.7 | nM | 5.74 |