Assay Detail
Binding
CHEMBL3106136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Mesulergine from 5-HT2C receptor (unknown origin)
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104091 | — | — | 2 | 8.00 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 7.52 |
| CHEMBL3104093 | — | — | 1 | - |
| CHEMBL3104092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104091 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3104091 | — | Ki | = | 10.47 | nM | 7.98 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3104093 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3104092 | — | Ki | > | 10000.0 | nM | - |