Assay Detail
Binding
CHEMBL3106137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin)
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.34 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 8.23 |
| CHEMBL42 | CLOZAPINE | 4.0 | 2 | 8.14 |
| CHEMBL3104091 | — | — | 2 | 7.62 |
| CHEMBL3104093 | — | — | 2 | 6.59 |
| CHEMBL3104092 | — | — | 2 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 5.888 | nM | 8.23 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL42 | CLOZAPINE | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL42 | CLOZAPINE | Ki | = | 7.413 | nM | 8.13 |
| CHEMBL3104091 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3104091 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL3104093 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL3104093 | — | Ki | = | 257.04 | nM | 6.59 |
| CHEMBL3104092 | — | Ki | = | 736.0 | nM | 6.13 |
| CHEMBL3104092 | — | Ki | = | 741.31 | nM | 6.13 |