Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3106286

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP-55,940 from CB1 receptor in rat brain by scintillation counting analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 1 (CHEMBL3571)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Controlled-deactivation cannabinergic ligands.
Sharma R, Nikas SP, Paronis CA, Wood JT, Halikhedkar A, Guo JJ, Thakur GA, Kulkarni S, Benchama O, Raghav JG, Gifford RS, Järbe TU, Bergman J, Makriyannis A.
J Med Chem (2013) 56 : 10142 -10157
PubMed 24286207 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 8.60 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3104360 1 9.52
CHEMBL3104358 1 9.22
CHEMBL3104362 1 9.15
CHEMBL3104356 1 8.80
CHEMBL3104354 1 7.57
CHEMBL267227 DELTA-8-TETRAHYDROCANNABINOL 2.0 1 7.32
CHEMBL3104363 1 -
CHEMBL3104361 1 -
CHEMBL3104359 1 -
CHEMBL3104357 1 -
CHEMBL3104355 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3104360 Ki = 0.3 nM 9.52
CHEMBL3104358 Ki = 0.6 nM 9.22
CHEMBL3104362 Ki = 0.7 nM 9.15
CHEMBL3104356 Ki = 1.6 nM 8.80
CHEMBL3104354 Ki = 27.1 nM 7.57
CHEMBL267227 DELTA-8-TETRAHYDROCANNABINOL Ki = 47.6 nM 7.32
CHEMBL3104363 Ki > 10000.0 nM -
CHEMBL3104361 Ki > 10000.0 nM -
CHEMBL3104359 Ki > 10000.0 nM -
CHEMBL3104357 Ki > 10000.0 nM -
CHEMBL3104355 Ki > 10000.0 nM -