Assay Detail
Binding
CHEMBL3106304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-CT from 5-HT1B receptor (unknown origin)
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.61 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 8.52 |
| CHEMBL3104092 | — | — | 2 | 6.15 |
| CHEMBL3104093 | — | — | 2 | 5.91 |
| CHEMBL3104091 | — | — | 2 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442 | ERGOTAMINE | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL442 | ERGOTAMINE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL3104092 | — | Ki | = | 715.0 | nM | 6.15 |
| CHEMBL3104092 | — | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL3104093 | — | Ki | = | 1218.0 | nM | 5.91 |
| CHEMBL3104093 | — | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL3104091 | — | Ki | = | 1363.0 | nM | 5.87 |
| CHEMBL3104091 | — | Ki | = | 1348.96 | nM | 5.87 |