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Assay Detail

CHEMBL3106348

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human OX1 receptor overexpressed in CHO-RD-HGA16 cells assessed as calcium mobilization after 15 mins by fluorescence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type RD-HGA16
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Orexin/Hypocretin receptor type 1 (CHEMBL5113)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Truncated Orexin Peptides: Structure-Activity Relationship Studies.
German NA, Decker AM, Gilmour BP, Thomas BF, Zhang Y.
ACS Med Chem Lett (2013) 4 : 1224 -1227
PubMed 24707347 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 28 6.26 9.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL438925 1 9.66
CHEMBL438397 1 8.08
CHEMBL412459 1 7.19
CHEMBL3103188 1 7.10
CHEMBL3103893 1 6.84
CHEMBL3103616 1 6.84
CHEMBL3103189 1 6.67
CHEMBL3105471 1 6.38
CHEMBL3105470 1 6.31
CHEMBL3105700 1 6.28
CHEMBL3105701 1 6.27
CHEMBL3105699 1 6.13
CHEMBL3103894 1 6.06
CHEMBL3105472 1 5.98
CHEMBL3103895 1 5.95
CHEMBL3103896 1 5.92
CHEMBL3105698 1 5.87
CHEMBL265424 1 5.86
CHEMBL3103892 1 5.86
CHEMBL3105702 1 5.81
CHEMBL3103618 1 5.72
CHEMBL3103187 1 5.72
CHEMBL3105468 1 5.61
CHEMBL3105473 1 5.51
CHEMBL3105474 1 5.51
CHEMBL3105703 1 5.51
CHEMBL3105469 1 5.49
CHEMBL3103186 1 5.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL438925 EC50 = 0.22 nM 9.66
CHEMBL438397 EC50 = 8.29 nM 8.08
CHEMBL412459 EC50 = 64.0 nM 7.19
CHEMBL3103188 EC50 = 78.9 nM 7.10
CHEMBL3103893 EC50 = 143.0 nM 6.84
CHEMBL3103616 EC50 = 144.0 nM 6.84
CHEMBL3103189 EC50 = 212.0 nM 6.67
CHEMBL3105471 EC50 = 422.0 nM 6.38
CHEMBL3105470 EC50 = 493.0 nM 6.31
CHEMBL3105700 EC50 = 526.0 nM 6.28
CHEMBL3105701 EC50 = 535.0 nM 6.27
CHEMBL3105699 EC50 = 739.0 nM 6.13
CHEMBL3103894 EC50 = 865.0 nM 6.06
CHEMBL3105472 EC50 = 1040.0 nM 5.98
CHEMBL3103895 EC50 = 1130.0 nM 5.95
CHEMBL3103896 EC50 = 1200.0 nM 5.92
CHEMBL3105698 EC50 = 1360.0 nM 5.87
CHEMBL265424 EC50 = 1380.0 nM 5.86
CHEMBL3103892 EC50 = 1370.0 nM 5.86
CHEMBL3105702 EC50 = 1560.0 nM 5.81
CHEMBL3103618 EC50 = 1910.0 nM 5.72
CHEMBL3103187 EC50 = 1900.0 nM 5.72
CHEMBL3105468 EC50 = 2480.0 nM 5.61
CHEMBL3105473 EC50 = 3070.0 nM 5.51
CHEMBL3105474 EC50 = 3060.0 nM 5.51
CHEMBL3105703 EC50 = 3070.0 nM 5.51
CHEMBL3105469 EC50 = 3230.0 nM 5.49
CHEMBL3103186 EC50 = 5700.0 nM 5.24