Assay Detail
Functional
CHEMBL3106372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human RPMI8226 cells assessed as cell viability after 72 hrs by MTT assay
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.86 | 5.03 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 5.03 |
| CHEMBL3104857 | — | — | 2 | 4.88 |
| CHEMBL3104856 | — | — | 2 | 4.67 |
| CHEMBL502377 | — | — | 1 | - |
| CHEMBL163876 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | IC50 | = | 9290.0 | nM | 5.03 |
| CHEMBL3104857 | — | IC50 | = | 13040.0 | nM | 4.88 |
| CHEMBL3104856 | — | IC50 | = | 21320.0 | nM | 4.67 |
| CHEMBL3104857 | — | Activity | - | — | - | |
| CHEMBL3104856 | — | Activity | - | — | - | |
| CHEMBL502377 | — | IC50 | - | — | - | |
| CHEMBL163876 | — | IC50 | - | — | - |