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Assay Detail

CHEMBL3106746

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Functional
Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum NF54 assessed as parasite growth inhibition by lactate dehydrogenase assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents.
Mjambili F, Njoroge M, Naran K, De Kock C, Smith PJ, Mizrahi V, Warner D, Chibale K.
Bioorg Med Chem Lett (2014) 24 : 560 -564
PubMed 24373723 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.35 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3104421 1 6.10
CHEMBL2441183 1 6.05
CHEMBL164087 1 6.00
CHEMBL351051 1 5.89
CHEMBL2441157 1 5.80
CHEMBL164422 1 5.77
CHEMBL572145 1 5.75
CHEMBL2441171 1 5.72
CHEMBL591362 1 5.66
CHEMBL3104428 1 5.57
CHEMBL490592 1 5.50
CHEMBL3104420 1 5.46
CHEMBL352267 1 5.41
CHEMBL2441158 1 5.28
CHEMBL3104423 1 5.26
CHEMBL2098389 1 5.23
CHEMBL162033 1 5.21
CHEMBL3104424 1 5.19
CHEMBL3104425 1 5.13
CHEMBL2098466 1 5.12
CHEMBL2441185 1 4.86
CHEMBL2441194 1 4.83
CHEMBL3104429 1 4.80
CHEMBL3104422 1 4.73
CHEMBL3104426 1 4.46
CHEMBL3104427 1 4.32
CHEMBL2441169 1 -
CHEMBL2441170 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3104421 IC50 = 800.0 nM 6.10
CHEMBL2441183 IC50 = 900.0 nM 6.05
CHEMBL164087 IC50 = 1000.0 nM 6.00
CHEMBL351051 IC50 = 1300.0 nM 5.89
CHEMBL2441157 IC50 = 1600.0 nM 5.80
CHEMBL164422 IC50 = 1700.0 nM 5.77
CHEMBL572145 IC50 = 1800.0 nM 5.75
CHEMBL2441171 IC50 = 1900.0 nM 5.72
CHEMBL591362 IC50 = 2200.0 nM 5.66
CHEMBL3104428 IC50 = 2700.0 nM 5.57
CHEMBL490592 IC50 = 3200.0 nM 5.50
CHEMBL3104420 IC50 = 3500.0 nM 5.46
CHEMBL352267 IC50 = 3900.0 nM 5.41
CHEMBL2441158 IC50 = 5300.0 nM 5.28
CHEMBL3104423 IC50 = 5500.0 nM 5.26
CHEMBL2098389 IC50 = 5900.0 nM 5.23
CHEMBL162033 IC50 = 6100.0 nM 5.21
CHEMBL3104424 IC50 = 6500.0 nM 5.19
CHEMBL3104425 IC50 = 7400.0 nM 5.13
CHEMBL2098466 IC50 = 7600.0 nM 5.12
CHEMBL2441185 IC50 = 13800.0 nM 4.86
CHEMBL2441194 IC50 = 14800.0 nM 4.83
CHEMBL3104429 IC50 = 15900.0 nM 4.80
CHEMBL3104422 IC50 = 18600.0 nM 4.73
CHEMBL3104426 IC50 = 35000.0 nM 4.46
CHEMBL3104427 IC50 = 47800.0 nM 4.32
CHEMBL2441169 IC50 > 35400.0 nM -
CHEMBL2441170 IC50 > 35400.0 nM -