Assay Detail
Binding
CHEMBL3106987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PFKFB3 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (CHEMBL2331053) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.22 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242739 | — | — | 1 | 6.17 |
| CHEMBL234338 | — | — | 1 | 5.53 |
| CHEMBL3105848 | — | — | 1 | 4.60 |
| CHEMBL3105838 | — | — | 1 | 4.57 |
| CHEMBL3105837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242739 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL234338 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL3105848 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3105838 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3105837 | — | IC50 | > | 1000000.0 | nM | - |