Assay Detail
Functional
CHEMBL3107220
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Cytotoxicity against human HeLa cells by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Trichodermone, a spiro-cytochalasan with a tetracyclic nucleus (7/5/6/5) skeleton from the plant endophytic fungus Trichoderma gamsii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.36 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.60 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 8.24 |
| CHEMBL479328 | ASPOCHALASIN D | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL479328 | ASPOCHALASIN D | IC50 | = | 5720.0 | nM | 5.24 |