Assay Detail
Functional
CHEMBL3107243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of proimflammatory activity in human primary epidermal keratinocytes assessed as IL-8 release after 6 hrs
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Keratinocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 7.86 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3105098 | — | — | 1 | 9.10 |
| CHEMBL3105095 | — | — | 1 | 8.96 |
| CHEMBL3105099 | — | — | 1 | 8.92 |
| CHEMBL3105094 | — | — | 1 | 8.82 |
| CHEMBL3105089 | — | — | 1 | 8.64 |
| CHEMBL3105027 | — | — | 1 | 8.64 |
| CHEMBL3105093 | — | — | 1 | 8.57 |
| CHEMBL3105023 | — | — | 1 | 8.52 |
| CHEMBL3105097 | — | — | 1 | 8.47 |
| CHEMBL3105096 | — | — | 1 | 8.43 |
| CHEMBL3105024 | — | — | 1 | 8.42 |
| CHEMBL3105091 | — | — | 1 | 8.36 |
| CHEMBL3105025 | — | — | 1 | 8.18 |
| CHEMBL3105106 | — | — | 1 | 8.09 |
| CHEMBL3105109 | — | — | 1 | 8.07 |
| CHEMBL1863513 | INGENOL MEBUTATE | 4.0 | 1 | 7.99 |
| CHEMBL3105111 | — | — | 1 | 7.92 |
| CHEMBL3105090 | — | — | 1 | 7.82 |
| CHEMBL3105100 | — | — | 1 | 7.80 |
| CHEMBL3102881 | — | — | 1 | 7.75 |
| CHEMBL3105108 | — | — | 1 | 7.70 |
| CHEMBL3105107 | — | — | 1 | 7.39 |
| CHEMBL3105092 | — | — | 1 | 7.38 |
| CHEMBL3105103 | — | — | 1 | 7.36 |
| CHEMBL3105105 | — | — | 1 | 7.29 |
| CHEMBL3105101 | — | — | 1 | 7.21 |
| CHEMBL3105102 | — | — | 1 | 7.21 |
| CHEMBL3105110 | — | — | 1 | 7.15 |
| CHEMBL3105104 | — | — | 1 | 6.95 |
| CHEMBL2430121 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3105098 | — | EC50 | = | 0.79 | nM | 9.10 |
| CHEMBL3105095 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3105099 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3105094 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3105089 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3105027 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3105093 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3105023 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3105097 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3105096 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3105024 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3105091 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3105025 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3105106 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL3105109 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL1863513 | INGENOL MEBUTATE | EC50 | = | 10.3 | nM | 7.99 |
| CHEMBL3105111 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3105090 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3105100 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3102881 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3105108 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3105107 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3105092 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3105103 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3105105 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3105101 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3105102 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3105110 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3105104 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL2430121 | — | EC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3105026 | — | EC50 | = | 534.0 | nM | 6.27 |
| CHEMBL3105088 | — | EC50 | = | 4520.0 | nM | 5.34 |