Assay Detail
Functional
CHEMBL3107245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of proimflammatory activity in human primary epidermal keratinocytes assessed as TNFalpha release after 6 hrs
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Keratinocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 7.79 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3105098 | — | — | 1 | 9.00 |
| CHEMBL3105095 | — | — | 1 | 8.85 |
| CHEMBL3105099 | — | — | 1 | 8.82 |
| CHEMBL3105094 | — | — | 1 | 8.80 |
| CHEMBL3105027 | — | — | 1 | 8.48 |
| CHEMBL3105093 | — | — | 1 | 8.40 |
| CHEMBL3105023 | — | — | 1 | 8.39 |
| CHEMBL3105096 | — | — | 1 | 8.30 |
| CHEMBL3105097 | — | — | 1 | 8.26 |
| CHEMBL3105091 | — | — | 1 | 8.24 |
| CHEMBL3105024 | — | — | 1 | 8.12 |
| CHEMBL3105089 | — | — | 1 | 8.09 |
| CHEMBL3105109 | — | — | 1 | 8.00 |
| CHEMBL1863513 | INGENOL MEBUTATE | 4.0 | 1 | 7.95 |
| CHEMBL3105106 | — | — | 1 | 7.92 |
| CHEMBL3105090 | — | — | 1 | 7.89 |
| CHEMBL3105100 | — | — | 1 | 7.85 |
| CHEMBL3105111 | — | — | 1 | 7.80 |
| CHEMBL3105025 | — | — | 1 | 7.72 |
| CHEMBL3102881 | — | — | 1 | 7.68 |
| CHEMBL3105108 | — | — | 1 | 7.55 |
| CHEMBL3105092 | — | — | 1 | 7.42 |
| CHEMBL3105105 | — | — | 1 | 7.27 |
| CHEMBL3105103 | — | — | 1 | 7.24 |
| CHEMBL3105102 | — | — | 1 | 7.08 |
| CHEMBL2430121 | — | — | 1 | 7.06 |
| CHEMBL3105110 | — | — | 1 | 7.01 |
| CHEMBL3105107 | — | — | 1 | 6.97 |
| CHEMBL3105101 | — | — | 1 | 6.70 |
| CHEMBL3105104 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3105098 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3105095 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3105099 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3105094 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3105027 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3105093 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3105023 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3105096 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3105097 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3105091 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3105024 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3105089 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL3105109 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1863513 | INGENOL MEBUTATE | EC50 | = | 11.2 | nM | 7.95 |
| CHEMBL3105106 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3105090 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3105100 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3105111 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3105025 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3102881 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3105108 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3105092 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3105105 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3105103 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3105102 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2430121 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3105110 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3105107 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL3105101 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3105104 | — | EC50 | = | 278.0 | nM | 6.56 |
| CHEMBL3105026 | — | EC50 | = | 632.0 | nM | 6.20 |
| CHEMBL3105088 | — | EC50 | - | — | - |