Assay Detail
Binding
CHEMBL3107402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX-2 in human whole blood assessed as prostaglandin E2 production by RIA
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.49 | 6.27 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.27 |
| CHEMBL3104539 | — | — | 1 | 5.85 |
| CHEMBL3104556 | — | — | 2 | 5.77 |
| CHEMBL3104551 | — | — | 1 | 4.86 |
| CHEMBL3104549 | — | — | 2 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3104539 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3104556 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3104551 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL3104549 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3104549 | — | Inhibition | - | % | - | |
| CHEMBL3104556 | — | Inhibition | - | % | - |