Assay Detail
Binding
CHEMBL3107433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741) after 45 mins by fluorescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.20 | 4.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491960 | CAMBINOL | — | 1 | 4.32 |
| CHEMBL3105180 | — | — | 1 | 4.23 |
| CHEMBL3105181 | — | — | 1 | 4.13 |
| CHEMBL3105182 | — | — | 1 | 4.10 |
| CHEMBL3105439 | — | — | 1 | - |
| CHEMBL3105184 | — | — | 1 | - |
| CHEMBL3105183 | — | — | 1 | - |
| CHEMBL3105179 | — | — | 1 | - |
| CHEMBL3105178 | — | — | 1 | - |
| CHEMBL3105177 | — | — | 1 | - |
| CHEMBL3105176 | — | — | 1 | - |
| CHEMBL3105175 | — | — | 1 | - |
| CHEMBL3105174 | — | — | 1 | - |
| CHEMBL3105173 | — | — | 1 | - |
| CHEMBL3105172 | — | — | 1 | - |
| CHEMBL3105171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491960 | CAMBINOL | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL3105180 | — | IC50 | = | 58430.0 | nM | 4.23 |
| CHEMBL3105181 | — | IC50 | = | 74520.0 | nM | 4.13 |
| CHEMBL3105182 | — | IC50 | = | 80110.0 | nM | 4.10 |
| CHEMBL3105439 | — | IC50 | - | — | - | |
| CHEMBL3105184 | — | IC50 | - | — | - | |
| CHEMBL3105183 | — | IC50 | - | — | - | |
| CHEMBL3105179 | — | IC50 | - | — | - | |
| CHEMBL3105178 | — | IC50 | - | — | - | |
| CHEMBL3105177 | — | IC50 | - | — | - | |
| CHEMBL3105176 | — | IC50 | - | — | - | |
| CHEMBL3105175 | — | IC50 | - | — | - | |
| CHEMBL3105174 | — | IC50 | - | — | - | |
| CHEMBL3105173 | — | IC50 | - | — | - | |
| CHEMBL3105172 | — | IC50 | - | — | - | |
| CHEMBL3105171 | — | IC50 | - | — | - |