Assay Detail
Functional
CHEMBL3107617
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Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum Dd2 after 72 hrs by SYBR Green 1-based fluorescence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.18 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.15 |
| CHEMBL3104733 | — | — | 1 | 6.70 |
| CHEMBL3104732 | — | — | 1 | 6.40 |
| CHEMBL514883 | KNIPHOLONE | — | 1 | 5.96 |
| CHEMBL3104866 | — | — | 1 | 5.89 |
| CHEMBL3104872 | — | — | 1 | 5.72 |
| CHEMBL3104868 | — | — | 1 | 5.60 |
| CHEMBL3104867 | — | — | 1 | 5.57 |
| CHEMBL3104742 | — | — | 1 | 5.30 |
| CHEMBL3104869 | — | — | 1 | 5.22 |
| CHEMBL3104870 | — | — | 1 | 5.10 |
| CHEMBL3104871 | — | — | 1 | 5.05 |
| CHEMBL3104874 | — | — | 1 | 5.05 |
| CHEMBL3104734 | — | — | 1 | 5.00 |
| CHEMBL3104735 | — | — | 1 | 5.00 |
| CHEMBL3104743 | — | — | 1 | 4.92 |
| CHEMBL3104864 | — | — | 1 | 4.85 |
| CHEMBL3104865 | — | — | 1 | 4.80 |
| CHEMBL3104740 | — | — | 1 | 4.75 |
| CHEMBL3104741 | — | — | 1 | 4.66 |
| CHEMBL3104873 | — | — | 1 | 4.58 |
| CHEMBL3104863 | — | — | 1 | 4.52 |
| CHEMBL3104737 | — | — | 1 | 4.51 |
| CHEMBL3104739 | — | — | 1 | 4.44 |
| CHEMBL3104736 | — | — | 1 | 4.38 |
| CHEMBL3104738 | — | — | 1 | 4.35 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 4.26 |
| CHEMBL41092 | CHRYSOPHANOL | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3104733 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3104732 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL514883 | KNIPHOLONE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3104866 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3104872 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3104868 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3104867 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3104742 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3104869 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3104870 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3104871 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3104874 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3104734 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3104735 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3104743 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3104864 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3104865 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3104740 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3104741 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3104873 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3104863 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3104737 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3104739 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3104736 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3104738 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL41092 | CHRYSOPHANOL | IC50 | = | 58000.0 | nM | 4.24 |