Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3107655

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of opioid receptor (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Opioid receptors; mu/kappa/delta (CHEMBL2095181)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.
Qiao JX, Wang TC, Ruel R, Thibeault C, L'Heureux A, Schumacher WA, Spronk SA, Hiebert S, Bouthillier G, Lloyd J, Pi Z, Schnur DM, Abell LM, Hua J, Price LA, Liu E, Wu Q, Steinbacher TE, Bostwick JS, Chang M, Zheng J, Gao Q, Ma B, McDonnell PA, Huang CS, Rehfuss R, Wexler RR, Lam PY.
J Med Chem (2013) 56 : 9275 -9295
PubMed 24164581 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.57 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3104636 1 5.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3104636 IC50 = 2700.0 nM 5.57