Assay Detail
Binding
CHEMBL3107684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [33P]-2MeS-ADP from human P2Y1 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysis
36
Total Activities
36
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.29 | 8.37 |
| IC50 | 2 | 6.88 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104636 | — | — | 1 | 8.37 |
| CHEMBL3105199 | — | — | 1 | 8.34 |
| CHEMBL3105201 | — | — | 1 | 8.24 |
| CHEMBL3104624 | — | — | 1 | 8.23 |
| CHEMBL2333770 | — | — | 1 | 8.22 |
| CHEMBL3103636 | — | — | 1 | 8.18 |
| CHEMBL3102866 | — | — | 1 | 8.14 |
| CHEMBL3103635 | — | — | 1 | 8.12 |
| CHEMBL3103625 | — | — | 1 | 8.06 |
| CHEMBL3105195 | — | — | 1 | 7.94 |
| CHEMBL3105200 | — | — | 1 | 7.89 |
| CHEMBL3104630 | — | — | 1 | 7.88 |
| CHEMBL3103627 | — | — | 1 | 7.80 |
| CHEMBL3104635 | — | — | 1 | 7.73 |
| CHEMBL3103626 | — | — | 1 | 7.69 |
| CHEMBL3104634 | — | — | 1 | 7.68 |
| CHEMBL3103634 | — | — | 1 | 7.58 |
| CHEMBL3105196 | — | — | 1 | 7.54 |
| CHEMBL3103630 | — | — | 1 | 7.53 |
| CHEMBL3103629 | — | — | 1 | 7.44 |
| CHEMBL3104625 | — | — | 1 | 7.44 |
| CHEMBL3103632 | — | — | 1 | 7.41 |
| CHEMBL3103631 | — | — | 1 | 7.19 |
| CHEMBL3103624 | — | — | 1 | 7.12 |
| CHEMBL3103633 | — | — | 1 | 7.03 |
| CHEMBL3104631 | — | — | 1 | 6.70 |
| CHEMBL3103623 | — | — | 1 | 6.64 |
| CHEMBL3105198 | — | — | 1 | 6.60 |
| CHEMBL3104633 | — | — | 1 | 6.52 |
| CHEMBL3104629 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104636 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL3105199 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL3105201 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL3104624 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL2333770 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3103636 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL3102866 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL3103635 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL3103625 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3105195 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL3105200 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL3104630 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL3103627 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3104635 | — | Ki | = | 18.6 | nM | 7.73 |
| CHEMBL3103626 | — | Ki | = | 20.3 | nM | 7.69 |
| CHEMBL3104634 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL3103634 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3105196 | — | Ki | = | 28.7 | nM | 7.54 |
| CHEMBL3103630 | — | Ki | = | 29.5 | nM | 7.53 |
| CHEMBL3104625 | — | Ki | = | 36.6 | nM | 7.44 |
| CHEMBL3103629 | — | Ki | = | 36.5 | nM | 7.44 |
| CHEMBL3103632 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL3103631 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL3103624 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3103633 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL3104631 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3103623 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL3105198 | — | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL3104633 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3104629 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL3105197 | — | Ki | = | 617.2 | nM | 6.21 |
| CHEMBL3104632 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL3103628 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL3104626 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL3104628 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL3104627 | — | Ki | = | 13500.0 | nM | 4.87 |