Assay Detail
Binding
CHEMBL3108367
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Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.66 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104784 | — | — | 1 | 7.90 |
| CHEMBL3104786 | — | — | 1 | 7.80 |
| CHEMBL3104778 | — | — | 1 | 7.10 |
| CHEMBL3104782 | — | — | 1 | 7.00 |
| CHEMBL3104780 | — | — | 1 | 6.60 |
| CHEMBL3104774 | — | — | 1 | 6.60 |
| CHEMBL3104777 | — | — | 1 | 6.50 |
| CHEMBL3104775 | — | — | 1 | 6.50 |
| CHEMBL3104773 | — | — | 1 | 6.10 |
| CHEMBL3104776 | — | — | 1 | 5.60 |
| CHEMBL3104781 | — | — | 1 | 5.60 |
| CHEMBL3104768 | — | — | 1 | - |
| CHEMBL3104779 | — | — | 1 | - |
| CHEMBL3104772 | — | — | 1 | - |
| CHEMBL3104771 | — | — | 1 | - |
| CHEMBL3104770 | — | — | 1 | - |
| CHEMBL3104769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104784 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL3104786 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL3104778 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL3104782 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3104780 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL3104774 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL3104777 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL3104775 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL3104773 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL3104776 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL3104781 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL3104768 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3104779 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3104772 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3104771 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3104770 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3104769 | — | Ki | > | 10000.0 | nM | - |