Assay Detail

CHEMBL3108370

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to NK1 receptor (unknown origin)

ChEMBL ↗

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Target

Substance-P receptor (CHEMBL249) ↗

Open DB target context

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Substance-P receptor (CHEMBL249) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Substance-P receptor

CHEMBL249

Anchored from Assay target.

Protein identity Substance-P receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Substance-P receptor (CHEMBL249) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists.

Hanessian S, Babonneau V, Boyer N, Mannoury la Cour C, Millan MJ, De Nanteuil G.
Bioorg Med Chem Lett (2014) 24 : 510 -514
PubMed 24374277 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	8.99	10.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1471	APREPITANT	4.0	1	10.10
CHEMBL3104784	—	—	1	7.88

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1471	APREPITANT	Ki	=	0.07943	nM	10.10
CHEMBL3104784	—	Ki	=	13.18	nM	7.88