Assay Detail
Binding
CHEMBL3111101
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Inhibition of CDK2/cyclin A3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.37 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319467 | — | — | 1 | 8.30 |
| CHEMBL122264 | — | — | 1 | 6.01 |
| CHEMBL269881 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319467 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL122264 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL269881 | — | IC50 | = | 16000.0 | nM | 4.80 |