Assay Detail
Binding
CHEMBL3111170
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Inhibition of human recombinant 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate after 10 mins
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.57 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3109719 | — | — | 1 | 6.55 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.25 |
| CHEMBL1668217 | — | — | 1 | 6.11 |
| CHEMBL3109717 | — | — | 1 | 6.10 |
| CHEMBL3109718 | — | — | 1 | 5.85 |
| CHEMBL501426 | — | — | 1 | 5.55 |
| CHEMBL3109724 | — | — | 1 | 5.50 |
| CHEMBL1668348 | — | — | 1 | 5.34 |
| CHEMBL443605 | HEXYLRESORCINOL | -1.0 | 1 | 5.34 |
| CHEMBL3109723 | — | — | 1 | 5.20 |
| CHEMBL3109722 | — | — | 1 | 5.13 |
| CHEMBL3109716 | — | — | 1 | 5.05 |
| CHEMBL3109721 | — | — | 1 | 5.03 |
| CHEMBL3109730 | — | — | 1 | 4.96 |
| CHEMBL3109726 | — | — | 1 | - |
| CHEMBL3109727 | — | — | 1 | - |
| CHEMBL3109728 | — | — | 1 | - |
| CHEMBL3109729 | — | — | 1 | - |
| CHEMBL1668215 | — | — | 1 | - |
| CHEMBL3109720 | — | — | 1 | - |
| CHEMBL3109725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3109719 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL93 | ZILEUTON | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1668217 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3109717 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3109718 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL501426 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3109724 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1668348 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL443605 | HEXYLRESORCINOL | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3109723 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3109722 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3109716 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3109721 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3109730 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3109726 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3109727 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3109728 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3109729 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1668215 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3109720 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3109725 | — | IC50 | > | 10000.0 | nM | - |