Assay Detail
Binding
CHEMBL3112014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GSK-3beta (unknown origin) using (RREGGMSRPAS(p)VDG as substrate assessed as 32P[gamma-ATP] incorporation into substrate after 15 mins by autoradiography
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.19 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355496 | — | — | 1 | 6.76 |
| CHEMBL3110144 | — | — | 1 | 6.62 |
| CHEMBL3110142 | — | — | 1 | 6.36 |
| CHEMBL3110140 | — | — | 1 | 6.16 |
| CHEMBL3110135 | — | — | 1 | 6.09 |
| CHEMBL3110143 | — | — | 1 | 6.03 |
| CHEMBL3110139 | — | — | 1 | 6.00 |
| CHEMBL3110138 | — | — | 1 | 5.92 |
| CHEMBL3110134 | — | — | 1 | 5.77 |
| CHEMBL3110141 | — | — | 1 | - |
| CHEMBL3110137 | — | — | 1 | - |
| CHEMBL3110136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355496 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL3110144 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3110142 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3110140 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3110135 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3110143 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3110139 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3110138 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3110134 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL3110141 | — | IC50 | - | — | - | |
| CHEMBL3110137 | — | IC50 | - | — | - | |
| CHEMBL3110136 | — | IC50 | - | — | - |