Assay Detail
Binding
CHEMBL3112165
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length HDAC1 using (Ac)Arg-Gly-Lys(Ac) as substrate after 60 mins by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.13 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.52 |
| CHEMBL3109980 | — | — | 1 | 4.77 |
| CHEMBL3110015 | — | — | 1 | 4.68 |
| CHEMBL3110001 | — | — | 1 | 4.66 |
| CHEMBL3109983 | — | — | 1 | 4.62 |
| CHEMBL3110021 | — | — | 1 | 4.50 |
| CHEMBL3110023 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3109980 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3110015 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3110001 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3109983 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3110021 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3110023 | — | IC50 | > | 50000.0 | nM | - |