Assay Detail
Binding
CHEMBL3112196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human brain TRPV1 expressed in HEK293T cells assessed as inhibition of CAP-induced intracellular Ca2+ influx by fluorescence-based assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 3 | - | - |
| IC50 | 3 | 6.98 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441472 | — | — | 2 | 9.82 |
| CHEMBL391997 | CAPSAZEPINE | — | 2 | 6.82 |
| CHEMBL182120 | VOACANGINE | — | 2 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441472 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL391997 | CAPSAZEPINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL182120 | VOACANGINE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL182120 | VOACANGINE | Inhibition | - | % | - | |
| CHEMBL441472 | — | Inhibition | - | % | - | |
| CHEMBL391997 | CAPSAZEPINE | Inhibition | - | % | - |