Assay Detail
Functional
CHEMBL3116802
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Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition by lactate dehydrogenase assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.64 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041980 | MMV-048 | 2.0 | 1 | 7.75 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 7.51 |
| CHEMBL3116043 | — | — | 1 | 7.37 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 6.85 |
| CHEMBL3116045 | — | — | 1 | 6.82 |
| CHEMBL3116042 | — | — | 1 | 6.80 |
| CHEMBL3116047 | — | — | 1 | 6.78 |
| CHEMBL3116032 | — | — | 1 | 6.71 |
| CHEMBL3116037 | — | — | 1 | 6.69 |
| CHEMBL3116039 | — | — | 1 | 6.68 |
| CHEMBL3116046 | — | — | 1 | 6.39 |
| CHEMBL3116031 | — | — | 1 | 6.32 |
| CHEMBL3116040 | — | — | 1 | 6.05 |
| CHEMBL3116044 | — | — | 1 | 5.70 |
| CHEMBL3116030 | — | — | 1 | 5.12 |
| CHEMBL3116041 | — | — | 1 | - |
| CHEMBL3116033 | — | — | 1 | - |
| CHEMBL3116034 | — | — | 1 | - |
| CHEMBL3116035 | — | — | 1 | - |
| CHEMBL3116036 | — | — | 1 | - |
| CHEMBL3116038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041980 | MMV-048 | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL3116043 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3116045 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL3116042 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3116047 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL3116032 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL3116037 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3116039 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL3116046 | — | IC50 | = | 404.0 | nM | 6.39 |
| CHEMBL3116031 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL3116040 | — | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL3116044 | — | IC50 | = | 2003.0 | nM | 5.70 |
| CHEMBL3116030 | — | IC50 | = | 7678.0 | nM | 5.12 |
| CHEMBL3116041 | — | IC50 | - | — | - | |
| CHEMBL3116033 | — | IC50 | - | — | - | |
| CHEMBL3116034 | — | IC50 | - | — | - | |
| CHEMBL3116035 | — | IC50 | - | — | - | |
| CHEMBL3116036 | — | IC50 | - | — | - | |
| CHEMBL3116038 | — | IC50 | - | — | - |