Assay Detail
Binding
CHEMBL3117140
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Inhibition of beta-lactamase KPC-2 in Klebsiella pneumoniae assessed as inhibition of hydrolysis of nitrocefin
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Klebsiella pneumoniae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.09 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3112752 | — | — | 1 | 8.52 |
| CHEMBL3112755 | — | — | 1 | 8.05 |
| CHEMBL3112751 | — | — | 1 | 8.00 |
| CHEMBL3112591 | — | — | 1 | 7.96 |
| CHEMBL3112748 | — | — | 1 | 7.44 |
| CHEMBL3112749 | — | — | 1 | 7.38 |
| CHEMBL3112747 | — | — | 1 | 7.38 |
| CHEMBL3112746 | — | — | 1 | 7.27 |
| CHEMBL3112753 | — | — | 1 | 7.11 |
| CHEMBL3112745 | — | — | 1 | 6.82 |
| CHEMBL3301605 | RELEBACTAM | 4.0 | 1 | 6.68 |
| CHEMBL3112757 | — | — | 1 | 6.65 |
| CHEMBL3112744 | — | — | 1 | 6.62 |
| CHEMBL3112756 | — | — | 1 | 6.61 |
| CHEMBL3112750 | — | — | 1 | 6.58 |
| CHEMBL3112743 | — | — | 1 | 6.58 |
| CHEMBL3112742 | — | — | 1 | 6.39 |
| CHEMBL3112754 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3112752 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3112755 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3112751 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3112591 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3112748 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3112749 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3112747 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3112746 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3112753 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3112745 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3301605 | RELEBACTAM | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3112757 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL3112744 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3112756 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL3112750 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3112743 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3112742 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3112754 | — | IC50 | = | 2500.0 | nM | 5.60 |