Assay Detail
Functional
CHEMBL3117229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel ring-A fused hybrids of oleanolic acid with capabilities to arrest cell cycle and induce apoptosis in breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.38 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3113074 | — | — | 1 | 4.97 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.96 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.62 |
| CHEMBL3113073 | — | — | 1 | 4.51 |
| CHEMBL3113068 | — | — | 1 | 4.14 |
| CHEMBL3113072 | — | — | 1 | 4.10 |
| CHEMBL1631518 | — | — | 1 | 4.10 |
| CHEMBL3113071 | — | — | 1 | 4.05 |
| CHEMBL3113069 | — | — | 1 | 4.01 |
| CHEMBL3113070 | — | — | 1 | - |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3113074 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL3113073 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL3113068 | — | IC50 | = | 71700.0 | nM | 4.14 |
| CHEMBL3113072 | — | IC50 | = | 78900.0 | nM | 4.10 |
| CHEMBL1631518 | — | IC50 | = | 78700.0 | nM | 4.10 |
| CHEMBL3113071 | — | IC50 | = | 88200.0 | nM | 4.05 |
| CHEMBL3113069 | — | IC50 | = | 96600.0 | nM | 4.01 |
| CHEMBL3113070 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 100000.0 | nM | - |