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Assay Detail

CHEMBL3117254

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Functional
Antimigratory activity in human MDA-MB-231 cells after 24 hrs by wound healing assay
ChEMBL ↗
113
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors.
Foudah AI, Sallam AA, Akl MR, El Sayed KA.
Eur J Med Chem (2014) 73 : 310 -324
PubMed 24487236 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 113 4.74 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3113311 — — 2 5.89
CHEMBL3113307 — — 2 5.62
CHEMBL3113308 — — 2 5.47
CHEMBL3113321 — — 2 5.46
CHEMBL3113293 — — 2 5.28
CHEMBL3113299 — — 1 5.23
CHEMBL3113312 — — 2 5.23
CHEMBL3113313 — — 2 5.21
CHEMBL3113296 — — 2 5.14
CHEMBL3113309 — — 2 5.11
CHEMBL3113101 — — 2 5.10
CHEMBL3113320 — — 2 5.03
CHEMBL3113297 — — 2 5.02
CHEMBL3113291 — — 2 4.97
CHEMBL3113292 — — 2 4.93
CHEMBL3113319 — — 2 4.92
CHEMBL3113300 — — 2 4.91
CHEMBL3113298 — — 2 4.91
CHEMBL3113301 — — 2 4.87
CHEMBL3113302 — — 2 4.86
CHEMBL3113314 — — 1 4.85
CHEMBL3113294 — — 2 4.80
CHEMBL3113098 — — 1 4.78
CHEMBL3113310 — — 2 4.75
CHEMBL3113100 — — 2 4.75
CHEMBL3113303 — — 1 4.75
CHEMBL3113315 — — 2 4.73
CHEMBL3113099 — — 2 4.69
CHEMBL3113295 — — 1 4.68
CHEMBL3113333 — — 2 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3113311 — IC50 = 1300.17 nM 5.89
CHEMBL3113311 — IC50 = 1300.0 nM 5.89
CHEMBL3113307 — IC50 = 2398.83 nM 5.62
CHEMBL3113307 — IC50 = 2400.0 nM 5.62
CHEMBL3113308 — IC50 = 3349.65 nM 5.47
CHEMBL3113308 — IC50 = 3400.0 nM 5.47
CHEMBL3113321 — IC50 = 3500.0 nM 5.46
CHEMBL3113321 — IC50 = 3483.37 nM 5.46
CHEMBL3113293 — IC50 = 5296.63 nM 5.28
CHEMBL3113293 — IC50 = 5300.0 nM 5.28
CHEMBL3113312 — IC50 = 5902.01 nM 5.23
CHEMBL3113299 — IC50 = 5900.0 nM 5.23
CHEMBL3113312 — IC50 = 5900.0 nM 5.23
CHEMBL3113313 — IC50 = 6100.0 nM 5.21
CHEMBL3113313 — IC50 = 6095.37 nM 5.21
CHEMBL3113296 — IC50 = 7194.49 nM 5.14
CHEMBL3113296 — IC50 = 7200.0 nM 5.14
CHEMBL3113309 — IC50 = 7798.3 nM 5.11
CHEMBL3113309 — IC50 = 7800.0 nM 5.11
CHEMBL3113101 — IC50 = 7906.79 nM 5.10
CHEMBL3113101 — IC50 = 7900.0 nM 5.10
CHEMBL3113320 — IC50 = 9289.66 nM 5.03
CHEMBL3113320 — IC50 = 9300.0 nM 5.03
CHEMBL3113297 — IC50 = 9506.05 nM 5.02
CHEMBL3113297 — IC50 = 9500.0 nM 5.02
CHEMBL3113291 — IC50 = 10592.54 nM 4.97
CHEMBL3113291 — IC50 = 10600.0 nM 4.97
CHEMBL3113292 — IC50 = 11803.21 nM 4.93
CHEMBL3113292 — IC50 = 11800.0 nM 4.93
CHEMBL3113319 — IC50 = 11912.42 nM 4.92
CHEMBL3113319 — IC50 = 11900.0 nM 4.92
CHEMBL3113300 — IC50 = 12189.9 nM 4.91
CHEMBL3113298 — IC50 = 12302.69 nM 4.91
CHEMBL3113300 — IC50 = 12200.0 nM 4.91
CHEMBL3113298 — IC50 = 12300.0 nM 4.91
CHEMBL3113301 — IC50 = 13396.77 nM 4.87
CHEMBL3113301 — IC50 = 13400.0 nM 4.87
CHEMBL3113302 — IC50 = 13900.0 nM 4.86
CHEMBL3113302 — IC50 = 13899.53 nM 4.86
CHEMBL3113314 — IC50 = 14100.0 nM 4.85
CHEMBL3113294 — IC50 = 16000.0 nM 4.80
CHEMBL3113294 — IC50 = 15995.58 nM 4.80
CHEMBL3113098 — IC50 = 16800.0 nM 4.78
CHEMBL3113310 — IC50 = 17900.0 nM 4.75
CHEMBL3113310 — IC50 = 17906.06 nM 4.75
CHEMBL3113100 — IC50 = 17988.71 nM 4.75
CHEMBL3113100 — IC50 = 18000.0 nM 4.75
CHEMBL3113303 — IC50 = 18000.0 nM 4.75
CHEMBL3113315 — IC50 = 18620.87 nM 4.73
CHEMBL3113315 — IC50 = 18600.0 nM 4.73