Assay Detail
Functional
CHEMBL3117733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by LANCE assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D₂/₃ receptors in their high-affinity state.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 9.74 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134807 | — | — | 1 | 10.70 |
| CHEMBL3115575 | — | — | 1 | 10.50 |
| CHEMBL3115585 | — | — | 1 | 10.30 |
| CHEMBL3115582 | — | — | 1 | 9.80 |
| CHEMBL3115579 | — | — | 1 | 9.40 |
| CHEMBL3115574 | — | — | 1 | 9.20 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | 4.0 | 1 | 9.20 |
| CHEMBL3115578 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134807 | — | EC50 | = | 0.01995 | nM | 10.70 |
| CHEMBL3115575 | — | EC50 | = | 0.03162 | nM | 10.50 |
| CHEMBL3115585 | — | EC50 | = | 0.05012 | nM | 10.30 |
| CHEMBL3115582 | — | EC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL3115579 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL3115574 | — | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL3115578 | — | EC50 | = | 1.585 | nM | 8.80 |