Assay Detail
Binding
CHEMBL3117734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
24
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D₂/₃ receptors in their high-affinity state.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.27 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | 4.0 | 2 | 5.99 |
| CHEMBL3115579 | — | — | 2 | 5.61 |
| CHEMBL3115585 | — | — | 2 | 5.56 |
| CHEMBL3115578 | — | — | 2 | 5.46 |
| CHEMBL3115574 | — | — | 2 | 5.45 |
| CHEMBL134807 | — | — | 2 | 5.43 |
| CHEMBL3115575 | — | — | 2 | 5.34 |
| CHEMBL3115582 | — | — | 2 | 5.01 |
| CHEMBL3115577 | — | — | 2 | 4.76 |
| CHEMBL3115581 | — | — | 2 | 4.71 |
| CHEMBL3115580 | — | — | 1 | - |
| CHEMBL3115576 | — | — | 1 | - |
| CHEMBL538542 | — | — | 1 | - |
| CHEMBL2106804 | NAXAGOLIDE HYDROCHLORIDE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | Ki | = | 1023.29 | nM | 5.99 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL3115579 | — | Ki | = | 2454.71 | nM | 5.61 |
| CHEMBL3115585 | — | Ki | = | 2754.23 | nM | 5.56 |
| CHEMBL3115579 | — | Ki | = | 2890.0 | nM | 5.54 |
| CHEMBL3115578 | — | Ki | = | 3480.0 | nM | 5.46 |
| CHEMBL3115578 | — | Ki | = | 3467.37 | nM | 5.46 |
| CHEMBL3115574 | — | Ki | = | 3548.13 | nM | 5.45 |
| CHEMBL134807 | — | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL134807 | — | Ki | = | 3830.0 | nM | 5.42 |
| CHEMBL3115574 | — | Ki | = | 3790.0 | nM | 5.42 |
| CHEMBL3115575 | — | Ki | = | 4570.88 | nM | 5.34 |
| CHEMBL3115575 | — | Ki | = | 4640.0 | nM | 5.33 |
| CHEMBL3115582 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL3115582 | — | Ki | = | 9772.37 | nM | 5.01 |
| CHEMBL3115577 | — | Ki | = | 17378.01 | nM | 4.76 |
| CHEMBL3115577 | — | Ki | = | 17800.0 | nM | 4.75 |
| CHEMBL3115581 | — | Ki | = | 19498.45 | nM | 4.71 |
| CHEMBL3115581 | — | Ki | = | 19700.0 | nM | 4.71 |
| CHEMBL3115585 | — | Ki | = | 27700.0 | nM | 4.56 |
| CHEMBL3115576 | — | Ki | - | — | - | |
| CHEMBL3115580 | — | Ki | - | — | - | |
| CHEMBL538542 | — | Ki | - | — | - | |
| CHEMBL2106804 | NAXAGOLIDE HYDROCHLORIDE | Ki | - | — | - |